Research On A flexible and multimodal biosensing patch integrated with microfluidics for chronic wound monitoring Got Featured On University and News Portals
A wearable biosensing patch for the monitoring of physiochemical parameters related to chronic wounds presents a promising approach to personalized wound management. Despite considerable advances in multimodal biosensing patches for wound care, fully integrated patches with microfluidic channels to monitor multiple parameters simultaneously are still a challenge. Herein, a flexible multimodal biosensing patch integrated with microfluidic channels is newly proposed. The patch comprises a polar array of seven biosensors fabricated on a flexible polyethylene terephthalate substrate. An SU-8-based microfluidic channel with arrowhead micropatterns is formed directly on the sensor via the lithography process. The integration of the microfluidic channels results in a fluid collection efficiency that is increased 6.5 times higher owing to the fluidic diode effect of the micropattern. The sensing platform is functionalized with a gold nanowire-incorporated reduced graphene oxide composite to fabricate an electrochemical biosensor array. This array is used in detecting three metabolites (glucose, lactate, and uric acid), two ions (Na+ and K+), pH, and temperature. The sensor responses are calibrated using a pH- and temperature-compensation algorithm to accurately quantify the analyte concentration and evaluate multi-sensing capability in the rat wound model. Its unique design and multiplexed sensing capacities offer significant advancements in nonhealing wound monitoring.
Web link:
https://doi.org/10.1016/j.cej.2024.157673
University Link:
https://www.kw.ac.kr/ko/life/research.jsp?BoardMode=view&DUID=48818
News article:
https://www.kyosu.net/news/articleView.html?idxno=129513
https://www.enewstoday.co.kr/news/articleView.html?idxno=2218575
https://news.unn.net/news/articleView.html?idxno=573046
https://www.m-i.kr/news/articleView.html?idxno=1193827
https://www.veritas-a.com/news/articleView.html?idxno=537161
https://www.popcornnews.net/news/articleView.html?idxno=70823
https://www.newsfreezone.co.kr/news/articleView.html?idxno=602489
